Table VI.
Logistic regression analyses of associations between IL-18 rs360719 A>G, IL-18R1 rs13015714 G>T, IL-18RAP rs917997 C>T and IL-28B rs8099917 T>G polymorphisms and risk of esophageal cancer lymph node metastasis.
| Genotype | LN meta (+) (n=85), n (%) | LN meta (−) (n=270), n (%) | Crude OR (95% CI) | P-value | Adjusted ORa (95% CI) | P-value |
|---|---|---|---|---|---|---|
| IL-18 rs360719 A>G | ||||||
| AA | 63 (75.9) | 185 (70.9) | 1.00 | 1.00 | ||
| AG | 18 (21.7) | 74 (28.4) | 0.71 (0.40–1.29) | 0.263 | 0.70 (0.39–1.27) | 0.241 |
| GG | 2 (2.4) | 2 (0.8) | 2.94 (0.41–21.28) | 0.287 | 2.66 (0.35–20.11) | 0.343 |
| GG vs. AG vs. AA | 0.255 | |||||
| AG+GG | 20 (24.1) | 76 (29.1) | 0.77 (0.44–1.37) | 0.375 | 0.76 (0.43–1.34) | 0.339 |
| AA+AG | 81 (97.6) | 259 (99.2) | 1.00 | 1.00 | ||
| GG | 2 (2.4) | 2 (0.8) | 3.20 (0.44–23.06) | 0.249 | 2.91 (0.39–21.86) | 0.299 |
| G allele | 22 (13.3) | 78 (14.9) | ||||
| IL-18R1 rs13015714 G>T | ||||||
| GG | 22 (26.8) | 73 (28.4) | 1.00 | 1.00 | ||
| GT | 41 (50.0) | 123 (47.9) | 1.11 (0.61–2.00) | 0.739 | 1.09 (0.60–1.98) | 0.782 |
| TT | 19 (23.2) | 61 (23.7) | 1.03 (0.51–2.09) | 0.927 | 1.04 (0.51–2.11) | 0.917 |
| TT vs. GT vs. GG | 0.941 | |||||
| GT+TT | 60 (73.2) | 184 (71.6) | 1.08 (0.62–1.89) | 0.782 | 1.07 (0.61–1.88) | 0.809 |
| GG+GT | 63 (76.8) | 196 (76.3) | 1.00 | 1.00 | ||
| TT | 19 (23.2) | 61 (23.7) | 0.97 (0.54–1.75) | 0.917 | 0.98 (0.54–1.78) | 0.957 |
| T allele | 79 (48.2) | 245 (47.7) | ||||
| IL-18RAP rs917997 C>T | ||||||
| CC | 20 (24.4) | 61 (23.6) | 1.00 | 1.00 | ||
| CT | 40 (48.8) | 120 (46.3) | 1.02 (0.55–1.89) | 0.958 | 0.99 (0.53–1.86) | 0.984 |
| TT | 22 (26.8) | 78 (30.1) | 0.86 (0.43–1.72) | 0.670 | 0.84 (0.42–1.70) | 0.635 |
| TT vs. CT vs. CC | 0.849 | |||||
| CT+TT | 62 (75.6) | 198 (76.4) | 0.96 (0.54–1.71) | 0.876 | 0.94 (0.52–1.68) | 0.824 |
| CC+CT | 60 (73.2) | 181 (69.9) | 1.00 | 1.00 | ||
| TT | 22 (26.8) | 78 (30.1) | 0.85 (0.49–1.48) | 0.569 | 0.85 (0.48–1.49) | 0.563 |
| T allele | 84 (51.2) | 276 (53.3) | ||||
| IL-28B rs8099917 T>G | ||||||
| TT | 75 (90.4) | 238 (91.2) | 1.00 | 1.00 | ||
| TG | 8 (9.6) | 21 (8.0) | 1.21 (0.51–2.84) | 0.664 | 1.20 (0.51–2.84) | 0.680 |
| GG | 0 (0.0) | 2 (0.8) | – | 0.990 | – | 0.990 |
| GG vs. TG vs. TT | 0.660 | |||||
| TG+GG | 8 (9.6) | 23 (8.8) | 1.10 (0.47–2.57) | 0.819 | 1.07 (0.46–2.51) | 0.872 |
| TT+TG | 83 (100) | 259 (99.2) | 1.00 | 1.00 | ||
| GG | 0 (0.0) | 2 (0.8) | – | 0.990 | – | 0.990 |
| G allele | 8 (4.8) | 25 (4.8) |
a
Adjusted for age, gender, smoking status and alcohol consumption. LN meta, lymph node metastasis; IL-18, interleukin-18; IL-18R1, IL-18 receptor 1; IL-18RAP, IL-18 receptor accessory protein; OR, odds ratio; CI, confidence interval.