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. Author manuscript; available in PMC: 2016 Dec 15.
Published in final edited form as: Biochemistry. 2015 Nov 30;54(49):7157–7167. doi: 10.1021/acs.biochem.5b01065

Figure 6. Addition of cholesterol changes the membrane topology of the C-terminal juxtamembrane region.

Figure 6

Accessibility data to NiEDDA (A) and oxygen (B), and interaction parameter (Ω) data (C) for M2TMC labeled at the indicated sites in POPC:POPG (4:1) bilayers with 0% and 30% cholesterol. Ω is the ratio of the central line intensity for fully-labeled and spin-diluted samples. Spectra used to calculate Ω are shown in Figure S2.