Table 4. Top canonical pathways associated to proteomic data sets.
| Pathway | *Frequency | B6 | CD1 | Aca23 | Time Point |
|---|---|---|---|---|---|
| Integrin-Linked (ILK) Signaling |
6/8 sets |
+ |
+ |
+ |
1, 6 weeks |
| Actin Cytoskeleton Signaling |
6/8 sets |
+ |
+ |
+ |
1, 6 weeks |
| Calcium Signaling |
3/8 sets |
+ |
- |
+ |
1 week |
| Cellular Effects of Sildenafil |
3/8 sets |
+ |
- |
+ |
1, 6 weeks |
| Protein Kinase A Signaling |
2/8 sets |
- |
+ |
- |
1,6 weeks |
| Rho Family GTPase Signaling | 2/8 sets | - | + | - | 1, 6 weeks |
* 8 sets include 1 and 6 weeks for the 3 strains (6 sets) and replicates for B6 and CD1 at 6 weeks (2 sets)