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. 2015 Sep 2;278(2):524–535. doi: 10.1148/radiol.2015150486

Figure 1:

Figure 1:

Imaging analysis pipeline. The 7-T quantitative multiecho (ME) T2* cortical maps were obtained voxel-wise by using Levenberg-Marquardt nonlinear regression analysis. Anatomic 3-T magnetization-prepared rapid acquisition with multiple gradient echo (MEMPR) images were processed by using FreeSurfer to reconstruct cortical surfaces and compute cortical thickness. Quantitative T2* maps were registered to the cortical surfaces, and sampled at 25%, 50%, and 75% depths from the pial surface. Diffusion weighted images (DWIs) were processed through the four steps of Tracts Constrained by Underlying Anatomy pipeline in FreeSurfer to, 1, generate DTI metrics, including fractional anisotropy (FA), radial diffusivity, and axial diffusivity maps; 2, run probabilistic tractography; 3, generate fractional anisotropy, radial diffusivity, and axial diffusivity profiles along WM paths in a patient’s native space; and, 4, to realign paths on the Montreal Neurologic Institute (MNI) template and generate fractional anisotropy, radial diffusivity, axial diffusivity profiles for group statistics. CT = cortical thickness, NAWM = normal-appearing WM, ROI = region of interest.