Abstract
Two adult cases of the Fanconi syndrome are described, in each of which there was abnormal urinary excretion of immunoglobulin κ-chain. The significance of this finding is discussed in relation to the recognized association between multiple myeloma and the Fanconi syndrome.
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Selected References
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- ARMSTRONG J. B. A study of renal function in patients with multiple myeloma. Am J Med Sci. 1950 May;219(5):488–493. doi: 10.1097/00000441-195005000-00003. [DOI] [PubMed] [Google Scholar]
- BUTLER E. A., FLYNN F. V. The proteinuria of renal tubular disorders. Lancet. 1958 Nov 8;2(7054):978–980. doi: 10.1016/s0140-6736(58)90473-2. [DOI] [PubMed] [Google Scholar]
- DEDMON R. E., WEST J. H., SCHWARTZ T. B. The adult Fanconi syndrome. Report of two cases, one with multiple myeloma. Med Clin North Am. 1963 Jan;47:191–206. doi: 10.1016/s0025-7125(16)33629-x. [DOI] [PubMed] [Google Scholar]
- DENT C. E., STOWES J. M. ADULT FANCONI SYNDROME AND CIRRHOSIS. Br Med J. 1965 Feb 20;1(5433):520–520. doi: 10.1136/bmj.1.5433.520. [DOI] [PMC free article] [PubMed] [Google Scholar]
- DRAGSTED P. J., HJORTH N. The association of the Fanconi syndrome with malignant disease. Dan Med Bull. 1956 Sep;3(6):177–179. [PubMed] [Google Scholar]
- ENGLE R. L., Jr, WALLIS L. A. Multiple myeloma and the adult Fanconi syndrome. I. Report of a case with crystal-like deposits in the tumor cells and in the epithelial cells of the kidney. Am J Med. 1957 Jan;22(1):5–23. doi: 10.1016/0002-9343(57)90333-9. [DOI] [PubMed] [Google Scholar]
- FISHER E. R., PEREZ-STABLE E., ZAWADZKI Z. A. ULTRASTRUCTURAL RENAL CHANGES IN MULTIPLE MYELOMA WITH COMMENTS RELATIVE TO THE MECHANISM OF PROTEINURIA. Lab Invest. 1964 Dec;13:1561–1574. [PubMed] [Google Scholar]
- Fahey J. L., Solomon A. TWO TYPES OF gamma-MYELOMA PROTEINS, beta(2A)-MYELOMA PROTEINS, gamma(1)-MACROGLOBULINS, AND BENCE JONES PROTEINS IDENTIFIED BY TWO GROUPS OF COMMON ANTIGENIC DETERMINANTS. J Clin Invest. 1963 Jun;42(6):811–822. doi: 10.1172/JCI104773. [DOI] [PMC free article] [PubMed] [Google Scholar]
- GOLDMAN R., ADAMS W. S., LUCHSINGER E. B. Renal function in multiple myeloma. J Lab Clin Med. 1952 Oct;40(4):519–522. [PubMed] [Google Scholar]
- GREENWALD H. P., BRONFIN G. J., AUERBACH O. Needle biopsy of the kidney; a report of five cases of multiple myeloma. Am J Med. 1953 Aug;15(2):198–206. doi: 10.1016/0002-9343(53)90071-0. [DOI] [PubMed] [Google Scholar]
- HARDWICKE J., SQUIRE J. R. The relationship between plasma albumin concentration and protein excretion in patients with proteinuria. Clin Sci. 1955 Aug;14(3):509–530. [PubMed] [Google Scholar]
- HARDWICKE J. The estimation of serum proteins by electrophoresis on filter paper. Biochem J. 1954 May;57(1):166–171. doi: 10.1042/bj0570166. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Harrison J. F., Northam B. E. Low molecular weight urine protein investigated by gel filtration. Clin Chim Acta. 1966 Nov;14(5):679–688. doi: 10.1016/0009-8981(66)90195-1. [DOI] [PubMed] [Google Scholar]
- MUNTENDAM H. Multipele myelomatosis en het syndroom van De Toni-Fanconi. Ned Tijdschr Geneeskd. 1958 Aug 30;102(35):1690–1693. [PubMed] [Google Scholar]
- OSSERMAN E. F. Natural history of multiple myeloma before radiological evidence of disease. Radiology. 1958 Aug;71(2):157–174. doi: 10.1148/71.2.157. [DOI] [PubMed] [Google Scholar]
- PARKINSON T. FANCONI'S SYNDROME. Proc R Soc Med. 1964 Jul;57:592–594. [PMC free article] [PubMed] [Google Scholar]
- PUTNAM F. W., EASLEY C. W., LYNN L. T., RITCHIE A. E., PHELPS R. A. The heat precipitation of Bence-Jones proteins. I. Optimum conditions. Arch Biochem Biophys. 1959 Jul;83(1):115–130. doi: 10.1016/0003-9861(59)90016-5. [DOI] [PubMed] [Google Scholar]
- RUFFIE R., BOUISSOU H., FOURNIE A., SUC J. M., PUTOIS J. LES MANIFESTATIONS R'ENALES DE LA MALADIE DE KAHLER. ETUDE ANATOMO-CLINIQUE. Rev Rhum Mal Osteoartic. 1963 Jun;30:348–354. [PubMed] [Google Scholar]
- SHORT I. A., SMITH J. P. Myelomatosis associated with glycosuria and aminoaciduria. Scott Med J. 1959 Feb;4(2):89–93. doi: 10.1177/003693305900400206. [DOI] [PubMed] [Google Scholar]
- SIROTA J. H., HAMERMAN D. Renal function studies in a adult subject with the Fanconi syndrome. Am J Med. 1954 Jan;16(1):138–152. doi: 10.1016/0002-9343(54)90329-0. [DOI] [PubMed] [Google Scholar]
- SOOTHILL J. F. Estimation of eight serum proteins by a gel diffusion precipitin technique. J Lab Clin Med. 1962 May;59:859–870. [PubMed] [Google Scholar]
- STEVENSON G. T. Further studies of the gamma-related proteins of normal urine. J Clin Invest. 1962 May;41:1190–1198. doi: 10.1172/JCI104572. [DOI] [PMC free article] [PubMed] [Google Scholar]
- TAKATSUKI K., OSSERMAN E. F. DEMONSTRATION OF TWO TYPES OF LOW MOLECULAR WEIGHT GAMMA-GLOBULINS IN NORMAL HUMAN URINE. J Immunol. 1964 Jan;92:100–107. [PubMed] [Google Scholar]