Table II.
Main characteristics of the eligible studies.
| First author, year | Patients, n (controls, n) | Ethnicity | Country | RNA extraction kits | Test method | AUC | QUADAS scores | Se% | Sp% | (Refs.) |
|---|---|---|---|---|---|---|---|---|---|---|
| Liu, 2013 | 200 (80) | Asian | China | Trizol-LS | RT-qPCR (Taqman) | 0.802 | 13 | 65 | 85 | (21) |
| Ogata-Kawata, 2014 | 88 (11) | Asian | Japan | Trizol-LS | miRNA microarray | 0.798 | 12 | 61.4 | 90.9 | (22) |
| Toiyama, 2013 | 186 (53) | Asian | Japan | miRNeasy RNA | RT-qPCR (Taqman) isolation kits | 0.927 | 13 | 82.8 | 90.6 | (24) |
| Kanaan, 2012 | 30 (30) | Caucasian | America | Trizol-LS | RT-qPCR (Taqman) | 0.82 | 13 | 90 | 90 | (25) |
| Wang, 2012 | 32 (39) | Asian | China | Trizol-LS | RT-qPCR (SYBR-Green) | 0.85 | 13 | 87.5 | 74.4 | (20) |
| Basati, 2014 | 40 (40) | Caucasian | Iran | mirVana | RT-qPCR (SYBR-Green) PARIS kit | 0.87 | 13 | 77 | 78 | (19) |
| Luo, 2013 | 80 (144) | Caucasian | Germany | Combination of Trizol LS and miRNeasy mini kit | RT-qPCR (Taqman) | 0.6528 | 13 | 51.7 | 80.7 | (23) |
| Zhang, 2014 | 41 (30) | Asian | China | Trizol-LS | RT-qPCR (Taqman) | 0.657 | 13 | 51.2 | 79 | (26) |
| Du, 2014 | 49 (49) | Asian | China | Trizol-LS | RT-qPCR (Taqman) | 0.877 | 13 | 76.2 | 93.2 | (27) |
AUC, area under the curve; QUADAS, Quality Assessment of Diagnostic Accuracy Studies; Se, sensitivity; Sp, specificity; RT-qPCR, reverse transcription-quantitative polymerase chain reaction.