Table III.

Univariate and multivariate Cox analyses of clinical variables for overall survival.

	Univariate analysis		Multivariate analysis
Variables	HR (95%CI)	P-value	HR (95%CI)	P-value
Age (≥60 vs. <60 years)	0.769 (0.603–1.092)	0.348
Gender (male vs. female)	1.143 (0.786–1.549)	0.864
Hepatitis virus infection		0.273
HBV	1.291 (0.659–1.754)
HCV	1.180 (0.783–1.651)
HBV and HCV	1.381 (0.832–1.903)
None	1.000
Child-Pugh class (A vs. B)	0.832 (0.595–1.087)	0.083
Bilirubin (>34 vs. ≤34 µmol/l)	1.069 (0.896–1.221)	0.290
AFP (≥200 vs. <200 ng/ml)	1.145 (0.917–1.365)	0.184
Tumor size (≥5 vs. <5 cm)	1.476 (1.189–1.841)	0.004	1.362 (0.982–1.754)	0.0593
Tumor nodularity (uninodular vs. multinodular)	1.293 (0.974–1.615)	0.059
Vascular invasion	1.384 (1.022–1.795)	0.041	1.185 (0.883–1.506)	0.136
Lymph node involvement	1.473 (1.085–1.890)	0.013	1.297 (0.944–1.672)	0.087
BCLC stage		<0.001
0	1.000		1.000
A	1.592 (1.225–1.931)		1.424 (1.116–1.758)	0.015
B	1.874 (1.416–2.385)		1.692 (1.285–2.136)	<0.001
C	2.136 (1.775–2.587)		1.921 (1.547–2.378)	<0.001
Serum IGF-1 (ng/ml)	0.752 (0.606–0.914)	0.005	0.824 (0.705–0.949)	0.009
Serum VEGF (pg/ml)	1.195 (1.092–1.287)	0.013	1.125 (1.058–1.196)	0.037

AFP, α-fetoprotein; BCLC, Barcelona Clinic Liver Cancer; CI, confidence interval; HBV, hepatitis B virus; HCV, hepatitis C virus; HR, hazard ratio; IGF-1, insulin-like growth factor-1; VEGF, vascular endothelial growth factor.