Association between plasma fibrinogen concentrations and clinicopathological characterisitcs in 275 patients with gastric cancer. The plasma fibrinogen concentration was significantly associated with (A) the depth of tumor invasion, (B) lymph node metastasis, (C) lymphatic invasion, (D) venous invasion and (E) tumor stage. Horizontal bars indicate the mean concentrations of plasma fibrinogen. (F) Receiver operating characteristic curve for discriminating between advanced and early gastric cancer based on plasma fibrinogen concentrations. pT1, invasion of lamina propria or submucosa; pT2, invasion of muscularis propria; pT3, invasion of subserosa; pT4, penetration of serosa or invasion of adjacent structures.