Association between NLR and clinicopathological characteristics in 275 patients with gastric cancer. The NLR was significantly associated with (A) the depth of tumor invasion, (B) lymph node metastasis, (C) lymphatic invasion, (D) venous invasion and (E) tumor stage. Horizontal bars indicate the mean NLR. (F) Receiver operating characteristic curve for discriminating between advanced and early gastric cancer based on NLR. NLR, neutrophil-lymphocyte ratio. pT1, invasion of lamina propria or submucosa; pT2, invasion of muscularis propria; pT3, invasion of subserosa; pT4, penetration of serosa or invasion of adjacent structures.