Table III.

Association between SOX2, Oct4, KLF4, c-Myc and brachyury positive expression ratio and clinicopathological factors in 108 oral squamous cell carcinoma patients.

		SOX2 expression, n			Oct4 expression, n			KLF4 expression, n			c-Myc expression, n			Brachyury expression, n
Clinicopathological parameter	Cases, n	Low	High	P-value	Low	High	P-value	Low	High	P-value	Low	High	P-value	Low	High	P-value
Age, years				0.56			0.846			0.846			0.332			0.560
<65	61	29	32		31	30		31	30		33	28		32	29
≥65	47	25	22		23	24		23	24		21	26		22	25
Gender				0.317			0.161			0.317			0.548			0.071
Male	69	32	37		31	38		32	37		33	36		30	39
Female	39	22	17		23	16		22	17		21	18		24	15
Clinical stage				0.550			0.048a			0.028a			0.845			0.420
T1	18	11	7		13	5		12	6		9	9		11	7
T2	46	24	22		22	24		27	19		25	21		25	21
T3	21	10	1		6	15		9	12		9	12		8	13
T4	23	9	14		13	10		6	17		11	12		10	13
Primary tumor site				0.030a			0.465			0.329			0.091			0.045a
Buccal mucosa	8	6	2		4	4		6	2		6	2		5	3
Upper gingiva	12	8	4		5	7		6	6		5	7		8	4
Lower gingiva	22	9	13		11	11		8	14		12	10		10	12
Tongue	55	29	26		30	25		28	27		29	26		29	26
Oral floor	10	1	9		3	7		6	4		1	9		2	8
Palate	1	1	0		1	0		0	1		1	0		0	1
Lymph node metastasis				1.000			0.046a			0.425			0.111			0.425
Positive	40	20	20		15	25		18	22		16	24		18	22
Negative	68	34	34		39	29		36	32		38	30		36	32
Distant metastasis				0.016a			0.244			0.081			0.500			0.081
Positive	9	1	8		3	6		2	7		4	5		2	7
Negative	99	53	46		51	48		52	47		50	49		52	47
Tumor differentiation				0.254			0.012a			0.820			0.110			0.110
Well	83	44	39		47	36		42	41		45	38		45	38
Moderate	25	10	15		7	18		12	13		9	16		9	16
Poor	0	0	0		0	0		0	0		0	0		0	0
Anneroth score				0.005a			0.019a			0.003a			0.019a			0.010a
1	7	3	4		6	1		5	2		4	3		5	2
2	14	12	2		6	8		9	5		10	4		10	4
3	54	30	24		31	23		31	23		29	25		27	27
4	33	9	24		11	22		9	24		11	22		12	21

^aSignificant. SOX2, sex determining region Y-box 2; Oct4, octamer-binding transcription factor 4; c-Myc, avian myelocytomatosis viral oncogene homolog; KLF4, Krüppel-like factor 4.