Table II.
Pathway functional enrichment analysis for down- and upregulated differentially expressed genes.
| Term | Pathway | Count | P-value |
|---|---|---|---|
| Downregulated DEGs | |||
| 04972 | Pancreatic secretion | 19 | 4.79E-12 |
| 04974 | Protein digestion and absorption | 13 | 9.90E-08 |
| 00260 | Glycine, serine and threonine metabolism | 8 | 9.43E-07 |
| 04964 | Proximal tubule bicarbonate reclamation | 6 | 1.78E-05 |
| 04950 | Maturity onset diabetes of the young | 6 | 2.99E-05 |
| 00980 | Metabolism of xenobiotics by cytochrome P450 | 8 | 4.11E-04 |
| 00982 | Drug metabolism-cytochrome P450 | 8 | 4.97E-04 |
| 00480 | Glutathione metabolism | 6 | 1.58 E-03 |
| 04971 | Gastric acid secretion | 7 | 2.65 E-03 |
| 04973 | Carbohydrate digestion and absorption | 5 | 4.96 E-03 |
| 04020 | Calcium signaling pathway | 11 | 5.38 E-03 |
| 04610 | Complement and coagulation cascades | 6 | 8.03 E-03 |
| 00250 | Alanine, aspartate and glutamate metabolism | 4 | 8.44 E-03 |
| 00750 | Vitamin B6 metabolism | 2 | 9.09 E-03 |
| 04976 | Bile secretion | 6 | 9.21 E-03 |
| Upregulated DEGs | |||
| 04110 | Cell cycle | 15 | 9.27E-06 |
| 04115 | p53 signaling pathway | 11 | 9.35E-06 |
| 04512 | ECM-receptor interaction | 10 | 3.77E-04 |
| 05200 | Pathways in cancer | 20 | 4.11E-03 |
| 05146 | Amoebiasis | 9 | 7.08E-03 |
| 05412 | Arrhythmogenic right ventricular cardiomyopathy | 7 | 9.61E-03 |
Count signifies the number of enriched DEGs. DEG, differentially expressed gene.