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. 2016 Feb 1;6:20314. doi: 10.1038/srep20314

Figure 2. MiR-155−/− resisted bleomycin induced skin fibrosis.

Figure 2

From day 0, miR-155−/− and wild type C57/BL6 (WT, B6) mice were injected subcutaneously with either a bleomycin (blm) solution (5 mg/ml) or saline (n.s.) every other day. Mice were sacrificed on day 21. (a) Representative skin and lung sections with H&E or Sirius red staining from each group. For Sirius red staining, red parts represent stained collagen and green parts represent total protein. Bars, 100 μm in skin sections and 50 μm in lung sections. (b) Thickness of dermis. N = 5 per group. **P < 0.01, ANOVA. (c) Collagen content of lesional skin measured by Sircol assay. N = 5 per group. *P < 0.05, ***P < 0.001, ANOVA. (d) Density of activated fibroblasts (α-SMA+) in each skin sample. N = 5 per group. *P < 0.05, ANOVA.