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. 2016 Feb 1;6:20314. doi: 10.1038/srep20314

Figure 3. Topical antagomiR-155 effectively treated bleomycin induced skin fibrosis.

Figure 3

(a) C57/BL6 mice were injected subcutaneously with either a bleomycin (blm) solution (1 mg/ml) or saline (n.s.). Topical antagomiR-155 (ant155) or scramble control (sc) was applied every other day from day 15. Mice were sacrificed on day 28. (b) MiR-155 expression in treated skin area on day 28. N = 7 per group. **P < 0.01, ANOVA. (c) Representative skin sections stained with Sirius red from each group. Red parts represent stained collagen and green parts represent total protein. Bars, 100 μm. (d) Thickness of dermis. N = 7 per group. **P < 0.01, ***P < 0.001, ANOVA. (e) Collagen content of lesional skin measured by Sircol assay. N = 7 per group. ***P < 0.001, ANOVA. (f) Density of activated fibroblasts (α-SMA+) in each skin sample. N = 7 per group. ***P < 0.001, ANOVA.