Fig. 1. Labeled PCA comparing sterile SIRS/trauma versus sepsis patients.
(A) Sterile SIRS/trauma and sepsis patients appear to be largely separable in the transcriptomic space, with only a minimal non-separable set. (B) The same labeled PCA is shown, with labels updated to reflect patients in recovery from noninfectious SIRS/trauma and patients with hospital-acquired sepsis; the late group (>48 hours after hospital admission) is much harder to separate. n = 1094 combined from 15 studies.