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. 2016 Jan 27;12:144–153. doi: 10.3762/bjoc.12.16

Table 1.

Iron-catalyzed aerobic oxidation of phenyl-substituted 4-benzylpyridines (1).a

graphic file with name Beilstein_J_Org_Chem-12-144-i001.jpg

Entry Substrate R Product Yield (%)b

1 1a H 2a 70
2 1b NH2 2b 55
3 1c SMe 2c 56
4 1d OMe 2d 67
5 1e Me 2e 79
6 1f I 2f 77
7 1g Br 2g 85
8 1h Cl 2h 66
9 1i F 2i 76
10 1j CO2Et 2j 61
11 1k CN 2k 79
12 1l NO2 2l 60

aReactions were performed on a 0.5 mmol scale in 1 mL of solvent using 1 atmosphere of O2 (balloon). bIsolated yields.