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The influence of the purification method on the amount of Fe impurities in papaveraldine (15) after oxidation.
| Entry | Purification method | Fe impurity in 15 (ppm) |
| 1 | Extractiona + column chromatographyb | 54 |
| 2 | Extractiona | 1097 |
| 3 | Extractiona + recrystallizationc | 300 |
aWashing subsequently with sat. aq NaHCO3 and brine, extraction with dichloromethane. bSilica flash cartridge applying a heptane/ethyl acetate gradient. cRecrystallization from a 2 M HCl solution.
