Table 1.

Effect of ligand and oxidant in gold-catalyzed oxidative C–H arylation of isoxazole 1a.^a

Entry	Au catalyst	Oxidant	Yield [%]b
			3aa	4a
1	AuCl(PPh3)	IBA	10	7
2	AuCl(IPr)	IBA	0	0
3	AuCl(PyC)	IBA	30	12
4	AuCl(PyC)	PhI(OAc)2	4	5
5	AuCl(PyC)	PhI(OCOCF3)2	3	4
6c	AuCl(PyC)	PhI(OH)(OTs)	9	5
7d	AuCl(PyC)	IBA	13	5
8c	AuCl(PyC)	IBA	0	9
9e	AuCl(PyC)	IBA	3	36

^aReaction conditions: 1a (0.20 mmol), 2a (0.20 mmol), Au catalyst (5 mol %), oxidant (0.20 mmol), (+)-10-camphorsulfonic acid (CSA, 0.20 mmol), CHCl₃/MeOH (10:1, 1.1 mL), 65 °C. ^bDetermined by GC analysis with n-nonane as an internal standard. ^cWithout CSA. ^dTsOH·H₂O was used instead of CSA. ^eCHCl₃ (1.0 mL) was used as solvent.