Scheme 1.
Preparation of benzoic acids 11–13; i. HIO4·2H2O (50%), AcOH, H2SO4, I2, H2O, 70 °C 24 h, 92%.; ii. Pd(OAc)2, Ph3P,Et3N, EtOH, CO (1 atm), 80 °C, 16 h. iii. HCl (6 M), 1,4-dioxane, 70 °C, 24 h or TFA/H2O (9:1), 100 °C, 24 h.
Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.