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. 2016 Jan 7;4:e1542. doi: 10.7717/peerj.1542

Table 2. IC50 values (μM) of doxorubicin (DOX) and cisplatin (CIS) in arginine-rich media (ARM) and arginine-free media (AFM).

Cells DOX (IC50 ± SD) CIS (IC50 ± SD)
ARM AFM ARM AFM
1. HeLa 1.66 ± 0.30* 4.07 ± 0.26* 77.36 ± 9.11* 54.07 ± 12.25*
2. Caco-2 33.55 ± 4.93 34.91 ± 5.70 105.88 ± 14.66 96.38 ± 32.03
3. MIA PaCa-2 14.60 ± 1.21 22.25 ± 3.35 72.01 ± 3.50 97.20 ± 20.34
4. BxPC-3 5.00 ± 0.74* 6.90 ± 0.53* 126.42 ± 34.07* 85.66 ± 3.81*
5. Hep G2 1.86 ± 0.38* 4.68 ± 1.08* 23.99 ± 2.75* 14.87 ± 1.22*
6. SK-HEP-1 7.92 ± 2.43* 11.09 ± 0.82* 117.40 ± 15.72 77.89 ± 17.77

Note:

Data from three independent experiments (n = 3) are represented as mean ± SD. The asterisk indicates a significant difference (at P < 0.05 analyzed using t-Test) in the cytotoxicity of the chemotherapeutic drug in cancer cells treated with arginine rich media (ARM) compared with arginin free media (AFM).