Table 3. IC₅₀ values (μM) of doxorubicin (DOX) alone and in combination with L-canavanine (L-CAV) (constant ratio).

N°	Cells	Drug alone				Combination of L-CAV and DOX
		L-CAV		DOX		Combination (L-CAV : DOX)	Molar ratio (L-CAV : DOX)	DOX (IC50 ± SD)	CI Value	Interaction
		(IC50 ± SD)	(IC70 ± SD)	(IC50 ± SD)	(IC30 ± SD)
						10 : 1	10 : 1	0.53 ± 0.03	0.1547	++++
1.	HeLa	216.9 ± 47.72	581.41 ± 106.99	4.07 ± 0.26	2.92 ± 0.65	IC50 : IC50	53.29 : 1	0.13 ± 0.02	0.0644	+++++
						IC70 : IC30	199.11 : 1	0.19 ± 0.07	0.2220	++++
						5 : 1	5 : 1	11.16 ± 2.79	0.4215	+++
2.	Caco-2	589.60 ± 138.92	1867.27 ± 623.99	34.91 ± 5.70	23.13 ± 2.46	IC50 : IC50	17.25 : 1	1.32 ± 0.32	0.0790	+++++
						IC70 : IC30	80.73 : 1	1.12 ± 0.05	0.1727	++++
						5 : 1	5 : 1	11.09 ± 2.41	0.5605	+++
3.	MIA PaCa-2	865.50 ± 315.30	3515.56 ± 978.67	22.25 ± 3.35	17.27 ± 3.04	IC50 : IC50	38.89 : 1	3.65 ± 0.61	0.3434	+++
						IC70 : IC30	203.56 : 1	2.34 ± 0.15	0.7562	++
						100 : 1	100 : 1	2.44 ± 0.29	0.4656	+++
4.	Bx-PC 3	2167 ± 282.84	3563.97 ± 345.07	6.90 ± 0.53	3.25 ± 0.36	IC50 : IC50	328.33 : 1	2.06 ± 0.08	0.6130	+++
						IC70 : IC30	1096.60 : 1	0.81 ± 0.18	0.6573	+++
						50 : 1	50 : 1	1.67 ± 0.28	0.4328	+++
5.	Hep G2	640.90 ± 164.68	1202.75 ± 397.31	4.68 ± 1.08	1.19 ± 0.39	IC50 : IC50	149.74 : 1	1.27 ± 0.30	0.4602	+++
						IC70 : IC30	1010.71 : 1	0.55 ± 0.05	0.9874	±
						10 : 1	10 : 1	3.03 ± 0.25	0.2989	++++
6.	SK-HEP-1	1179 ± 149.08	2018.37 ± 678.23	11.09 ± 0.82	3.75 ± 0.73	IC50 : IC50	105.36 : 1	2.25 ± 0.02	0.3985	+++
						IC70 : IC30	538.23 : 1	0.42 ± 0.06	0.2296	++++

Note:

Data from three independent experiments (n = 3) are represented as mean ± SD.