Table IV.

Univariable and multivariable Cox regression analysis of overall survival rate of ccRCC patients.

	Univariable analysis		Multivariable analysis
Parameters	P-value	HR (95 CI)	P-value	HR (95 CI)
Gender
Female vs. male	0.069	2.38 (0.93–6.11)
Age (years)
>62 vs.≤62	0.42	0.69 (0.27–1.71)
Tumor size (cm)
>7 vs.≤7	0.46	0.71 (0.29–1.75)
Tumor grade
T3+4 vs. T1+2	0.0001	8.37 (2.76–25.35)	0.28	1.95 (0.57–6.64)
Histological grade
F3+4 vs. F1+2	<0.0001	34.08 (4.50–258.08)	0.007	18.28 (2.19–152.39)
RASSF1A mRNA levels
(≤0.266) vs. (>0.266)	0.004	6.06 (1.76–20.91)	0.02	2.25 (0.62–8.12)
RASSF1A methylation
(>25) vs. (≤25%)	0.02	3.00 (1.18–7.65)	0.22	1.88 (0.68–5.18)
RASSF1A protein levels
(≤10.09) vs. (>10.09)	0.32	0.54 (0.15–1.85)
RASSF1C mRNA levels
(>0.191) vs. (≤0.191)	0.83	0.91 (0.34–2.37)
RASSF1C protein levels
(>3.03) vs. (≤0.191)	0.35	2.01 (0.46–8.72)