Table V.

Univariable and multivariable Cox regression analysis of progression free-survival rate of ccRCC patients.

	Univariable analysis		Multivariable analysis
Parameters	P-value	HR (95 CI)	P-value	HR (95 CI)
Gender
Female vs. male	0.049	2.37 (1.01–5.64)	0.55	1.33 (0.52–3.39)
Age (years)
>62 vs.≤62	0.19	0.57 (0.25–1.32)
Tumor size (cm)
>7 vs.≤7	0.61	0.81 (0.35–1.84)
Tumor grade
T3+4 vs. T1+2	0.003	3.57 (1.51–8.47)	0.73	1.67 (0.47–2.88)
Histological grade
F3+4 vs. F1+2	0.005	33.86 (4.54–252.35)	0.006	18.81 (2.26–156.32)
RASSF1A mRNA levels
(≤0.266) vs. (>0.266)	0.001	10.40 (2.43–44.51)	0.019	2.93 (0.59–14.43)
RASSF1A methylation
(>25%) vs. (≤25%)	0.28	1.56 (0.69–3.55)
RASSF1A protein levels
(≤10.09) vs. (>10.09)	0.43	0.65 (0.22–1.9)
RASSF1C mRNA levels
(>0.191) vs. (≤0.191)	0.67	0.82 (0.34–2.01)
RASSF1C protein levels
(>3.03) vs. (≤0.191)	0.12	4.83 (0.64–35.85)