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. Author manuscript; available in PMC: 2016 Dec 1.
Published in final edited form as: Arch Toxicol. 2015 Nov 13;89(12):2197–2205. doi: 10.1007/s00204-015-1633-3

Figure 2.

Figure 2

a. After entering cells, cisplatin loses chloride ligands to form [Pt(NH3)2Cl(OH2)]+ and [Pt(NH3)2(OH2)2]2+. b. Aquated cisplatin interact with DNA to form 1,2-intrastrand crosslink (including 1,2-GpG and 1,2-ApG), 1,3-intrastrand crosslink and interstrand crosslink.