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. Author manuscript; available in PMC: 2016 Oct 6.
Published in final edited form as: Anal Chem. 2015 Sep 10;87(19):10096–10102. doi: 10.1021/acs.analchem.5b02766

Figure 2.

Figure 2

CTC detection from healthy and transgenic mice using an anti-EGFR-G7 dendrimer-immobilized platform. a) An illustration of the experiment independently using wild-type FVB/N mice and CEO transgenic mice. b) Comparison of the captured cell numbers per 100 μL blood between two groups on the anti-EGFR-dendrimer surfaces. A significantly higher number of CTCs (75.3 ± 14.9 CTCs per 100 μL, n=7) was captured from the transgenic mice than that (4.4 ± 1.2 CTCs per 100 μL, n=6, p=0.0011) from wild-type controls. (Mean ± S.E., **p<0.005) c) An immunostaining scheme of the captured cells and d) its representative images: i) DAPI staining, ii) cytokeratin staining, and iii) CD45 staining. The cell with a white arrow was identified as a CTC.