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. Author manuscript; available in PMC: 2016 Feb 1.
Published in final edited form as: J Dev Biol. 2015 Dec 14;3(4):129–157. doi: 10.3390/jdb3040129

Figure 5.

Figure 5

Spindle orientation to cell-adhesion cues. (A) Drosophila male germ line stem cells (mGSCs) form adherens junctions with a central hub cell and orient their mitotic spindles relative to this junction through the activity of the APC2 protein. Following division, the hub-proximal cell retains a stem cell fate, whereas the hub-distal cell becomes a gonial blast (GB) that differentiates further during spermatogenesis. Additionally, the GSC inherits the mother centrosome, while the daughter centrosome is segregated into the GB; (B) T-cell maturation initiates upon interaction with an APC at a specialized cell junction called the immunological synapse, mediated though interactions with CD8/CD4 receptors on the T-cell surface. APC interaction induces cell polarity in the T-cell, with Scribble (Scrib) localizing along the synapse and aPKC along the opposite cortical surface. Spindle orientation relative to the synapse generates a proximal and distal cell that differentiate into the Effector and Memory cell, respectively.