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TrkA activity for 41–44
| ||
|---|---|---|
| Compound | R1 (A-region) | %TrkA inhibition,a 20 μM |
| 41 | 4-1-Methyl-1H-pyrazole | 46 ± 2.3 |
| 42 | 5-Pyrimidine | 77 ± 1.2 |
| 43 | –Cl | 47 ± 1.4 |
| 44 | 3-Thiophene | 17 ± 3.9 |
The amount of activity at a 20 μM concentration of inhibitor: 100 is complete inhibition, 0 is complete activity. Completed in quadruplicate.
