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(A and B) Four and eight days (indicated by black arrows) after i.c. tumor implantation, mice received intratumoral (i.t.) injections of SWCNT/CpG-2, RSS-CpG or PBS. TMZ (2.5 mg/kg) was administered daily beginning on day 4. Kaplan–Meier analysis showed SWCNT/CpG-2+TMZ significantly extended survival relative to all other treatment groups (curves significantly different P < 0.0001 by Log-rank test, n = 5).
