Table 3. DEG Process Analysis.

Involvement	Case A	Case B	Case C
Bone tissue development or pathology onset	(18up+7down) ~9%	(7up+9down) ~9%	(7up) ~24%
Calcium aspects	(8up+8down) ~6%	(5up+5 down) ~6%	(1up+1down) ~7%
Cell differentiation	(8up+4down) ~4%	(3up+4down) ~4%	(2up) ~7%
Extracellular matrix interaction	(11up+9down) ~8%	(9up+11down) ~11%	(5up+1down) ~21%
Inflammatory response	(8up+1down) ~3%	(6up+1down) ~4%	(2up) ~7%

Identification of DEG’ mostly related biological process (considered for each comparison). The complete list of DEG was manually screened relying on Entrez Gene annotations: the most recurrent biological processes were highlighted and genes involved in them were counted in order to obtain statistics.