Table 4. Functional Annotation Clusters.
| Comparison | Enrichment score |
|---|---|
| Case A | |
| Inflammatory response | 9.15 |
| Cell differentiation | 7.54 |
| Bone development | 7.51 |
| Collagen fibril organization | 7.00 |
| Calcium ion binding | 2.58 |
| Case B | |
| Bone development | 5.38 |
| Cell differentiation | 5.16 |
| Cell adhesion | 4.29 |
| Inflammatory response | 4.28 |
| Response to calcium ion | 3.00 |
| Case C | |
| Inflammatory response | 2.93 |
| Cell differentiation | 2.46 |
| Bone development | 1.73 |
| Calcium ion binding | 1.73 |
Functional annotation clusters related to bone formation have been identified for each comparison. Each cluster is presented with its group enrichment score, which ranks the biological significance of gene groups relying on the geometric mean of EASE scores [64] of terms involved in this cluster.