Table 2.
Most common adverse events of all grades by siltuximab trial
| Adverse events in clinical studies | % of adverse events |
|---|---|
| Phase I (Kurzrock et al)24 | |
| Thrombocytopenia | 25 |
| Neutropenia | 19 |
| Hypertriglyceridemia | 19 |
| Leukopenia | 18 |
| Hypercholesterolemia | 15 |
| Phase II (van Rhee et al)27 | |
| URI | 89 |
| Nausea | 63 |
| Vomiting | 58 |
| Diarrhea | 53 |
| Hypercholesterolemia | 15 |
| RCT (van Rhee et al)23 | |
| Pruritus | 42 |
| URI | 36 |
| Fatigue | 34 |
| Rash | 34 |
| Peripheral edema | 32 |
Abbreviations: RCT, randomized, controlled trial; URI, upper respiratory tract infection.