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. 2016 Jan 27;11:449–463. doi: 10.2147/IJN.S93541

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Images of therapeutic effect in vivo.

Notes: (A) Morphology of all tumors isolated from the sacrificed mice in each group after 7 days of administration. (B) The six images are representative H&E staining of tumors. (B(a)–B(f)) The image of tumor treated with normal saline control, EPTN, RS, FS, RPN, and RPTN, respectively. The tissue slices were H&E stained and observed by microscope (×400).

Abbreviations: H&E, hematoxylin and eosin; EPTN, empty poly(lactic-co-glycolic acid)-d-α-tocopheryl polyethylene glycol 1000 succinate nanoparticle; RS, Resibufogenin solution; FS, 5-fluorouracil solution; RPN, Resibufogenin-loaded poly(lactic-co-glycolic acid) nanoparticle; RPTN, Resibufogenin-loaded poly(lactic-co-glycolic acid)-d-α-tocopheryl polyethylene glycol 1000 succinate nanoparticle.