Table 1.
Characterization of nanoparticles (n=6, mean ± SD)
| Group | Polymer | Size (nm) | Polydispersity index | Zeta potential (mV) | Drug loading (%) | Encapsulation efficiency (%) |
|---|---|---|---|---|---|---|
| RPTN | PLGA-TPGS | 152.3±2.5 | 0.082±0.015 | −24.12±0.21 | 18.38±0.26 | 79.32±1.17 |
| RCPTN | PLGA-TPGS | 154.6±2.6 | 0.076±0.021 | −23.76±0.24 | 9.16±0.28 | 79.67±1.23 |
| RPN | PLGA | 331.7±2.9 | 0.179±0.029 | −15.78±0.26 | 15.13±0.27 | 68.63±1.58 |
Abbreviations: SD, standard deviation; RPTN, Resibufogenin-loaded PLGA-TGPS nanoparticle; PLGA-TPGS, poly(lactic-co-glycolic acid)-d-α-tocopheryl polyethylene glycol 1000 succinate; RCPTN, Resibufogenin/coumarin-6-loaded PLGA-TPGS nanoparticle; RPN, Resibufogenin-loaded PLGA nanoparticle.