Table 3.
TIliver and SI values of RCPTN in mice at different time points after tail intravenous administration
| Index | Time (hours)
|
|||||||
|---|---|---|---|---|---|---|---|---|
| 0.08 | 0.5 | 1 | 2 | 4 | 8 | 12 | 24 | |
| TIliver | 1.9 | 3.4 | 11.3 | 19.4 | 15.8 | 10.8 | 8.8 | 7.0 |
| SIplasma | 0.1 | 1.7 | 4.3 | 4.0 | 4.9 | 18.0 | – | – |
| SIheart | – | – | 9.7 | 12.1 | 13.2 | – | – | – |
| SIspleen | 1.3 | 3.0 | 4.1 | 3.1 | 2.9 | 2.3 | 3.4 | – |
| SIlung | 1.6 | 3.5 | 4.9 | 4.6 | 4.6 | 3.2 | 4.9 | – |
| SIkidney | – | – | 12.4 | 13.9 | 11.3 | – | – | – |
Abbreviations: TI, targeting index; SI, selectivity index; RCPTN, Resibufogenin/coumarin-6-loaded poly(lactic-co-glycolic acid)-d-α-tocopheryl polyethylene glycol 1000 succinate nanoparticle.