Table 4.
AUC (n=10, mean ± SD), and Re and Te values of RBG in RCPTN and RS in plasma and different organs of mice
| Group | Plasma | Liver | Heart | Spleen | Lung | Kidney |
|---|---|---|---|---|---|---|
| AUCRCPTN(μg/mL) | 15.3±1.2 | 130.0±2.3# | 4.1±0.8 | 36.2±1.7# | 25.5±1.9# | 4.0±1.3 |
| AUCRS(μg/mL) | 18.6±2.1 | 2.1±0.9 | 3.7±0.9 | 2.2±0.6 | 2.5±0.8 | 2.7±1.0 |
| Re | 0.8 | 63.3 | 1.1 | 16.4 | 10.3 | 1.5 |
| TeRCPTN | 8.5 | – | 31.7 | 3.6 | 5.1 | 32.5 |
| TeRS | 0.1 | – | 0.6 | 1.0 | 0.8 | 0.8 |
Note:
#
P<0.01 versus corresponding RS group.
Abbreviations: AUC, area under the concentration–time curve; SD, standard deviation; Re, relative targeting efficiency; Te, targeting efficiency; RBG, Resibufogenin; RCPTN, RBG/coumarin-6-loaded poly(lactic-co-glycolic acid)-d-α-tocopheryl polyethylene glycol 1000 succinate nanoparticle; RS, RBG solution.