Table 5.
Increment tumor volumes and the tumor inhibition rates of various groups on mice (mean ± SD)
| Group | Number of natural deaths | Volume growth (n=8, cm3) |
Tumor weight (n=8, g) |
IR (%) |
MRBG in tumor (n=6, μg) |
MRBG in tumor/g (n=6, μg/g) |
|---|---|---|---|---|---|---|
| Blank control group (saline) | 3 | 5.73±1.38 | 5.19±1.13 | – | – | – |
| EPTN | 3 | 5.57±1.24 | 5.08±0.92 | 2.12 | – | – |
| RS | 2 | 3.16±0.78 | 3.55±0.71 | 31.60 | 0.19±0.08 | 0.05±0.02 |
| FS | 1 | 3.05±0.72* | 3.26±0.74* | 37.19 | – | – |
| RPN | 0 | 2.14±0.63* | 2.51±0.68* | 51.64 | 2.54±0.46a | 1.01±0.16a |
| RPTN | 0 | 1.45±0.38# | 1.82±0.65# | 64.93 | 3.70±0.69b | 2.05±0.39b |
Notes:
*
P<0.05 and
#
P<0.01 versus the blank control group, respectively;
a
P<0.05 and
b
P<0.01 versus RS group, respectively.
Abbreviations: SD, standard deviation; IR, inhibition rate; RBG, Resibufogenin; EPTN, empty poly(lactic-co-glycolic acid)-d-α-tocopheryl polyethylene glycol 1000 succinate nanoparticle; RS, RBG solution; FS, 5-fluorouracil solution; RPN, RBG-loaded poly(lactic-co-glycolic acid) nanoparticle; RPTN, RBG-loaded poly(lactic-co-glycolic acid)-d-α-tocopheryl polyethylene glycol 1000 succinate nanoparticle; MRBG, mass of RBG.