Table 2.

Representation of reactivation status of ex vivo cultures of CD8⁺‐depleted PBMCs isolated from HIV⁺ patients

One night after cell purification, cells were mock‐treated or treated with 5‐AzadC. Three days post‐treatment, 1/3 of medium was removed and HDACIs were added in the cultures. Six days after 5‐AzadC treatment, the concentration of viral RNA in culture supernatants was determined (in copies/ml; ND means undetectable, and NA indicates an untested condition). Total HIV‐1 DNA is expressed as total HIV‐1 DNA copies/10⁶ CD8⁺‐depleted PBMCs. The cultures highlighted in gray showed a higher viral production with the LRA combination than with the corresponding LRAs alone, while the cultures highlighted in black were reactivated only by the combinatory treatment and not by the LRAs individually. Patients indicated by the # symbol are only reactivated by one or more combinations.