Figure 2. Hypothesized interaction between affect and cognition in major depression (MD) and schizophrenia (SCZ). This schematic highlights the potential interplay between emotional and cognitive computations that may be affected in MD and SCZ. It selves to highlight the intuition that affective and cognitive processing operates at multiple temporal scales and interacts in different ways across these scales. Future studies that attempt to parse the nature of cross-diagnostic affective deficits in SCZ and MD may consider a broader perspective of affect and cognition as integrally linked computations sub-serving linked behavioral dimensions,¹⁴ which can “dysinteract” in complex ways across diagnostic categories.¹³ .