TABLE 1.
Choice of infusion method (infusion volume, rate).
Volume (based on body weight)
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Body weight | Target | Concentration | 15–20 g | 20–30 g | 30–45 g | 45–60 g | Infusion rate | Infusion time (20–30 g) |
CFDA-SE | Duct cells | 10 μM | 25 μl | 30 μl | 35 μl | 35 μl | 1 μl/min | 30 min |
DDAO-SE | Duct cells | 10 μM | 25 μl | 30 μl | 35 μl | 35 μl | 1 μl/min | 30 min |
AAV6-Sox9P-X | Duct cells | 1012 GCPs/ml | 25 μl | 30 μl | 35 μl | 35 μl | 1 μl/min | 30 min |
AAV8-CMV-X | All pancreatic cells | 1012 GCPs/ml | 120 μl | 150 μl | 165 μl | 180 μl | 6 μl/min | 25 min |
AAV8-RIP-X | Beta cells | 1012 GCPs/ml | 120 μl | 150 μl | 165 μl | 180 μl | 6 μl/min | 25 min |
GCPs, genome copy particles.