TABLE 2.

Transduction efficiency of AAV infusion.

Transduction efficiency (%)	Acinar cells	Duct cells	Beta cells	Alpha cells
AAV8-CMV-GFP	84.5 ± 7.9	1.2 ± 0.4	71.5 ± 9.2	65.9 ± 8.2
AAV6-CMV-GFP	55.1 ± 7.3	44.2 ± 6.4	23.9 ± 5.5	18.6 ± 4.5
AAV8-RIP-GFP	<0.1%	<0.1%	75.6 ± 7.6	<0.1%

The infusion was performed on 20–30-g mice, and thus 150 μl of 10¹² GCPs/ml AAV was infused at a rate of 6 μl/min. Quantification was performed from five mice in each condition, and was presented as mean ± s.e.m. For duct labeling efficiency and specificity by CFDA-SE, or by AAV6-Sox9p-Cre to R26RR^Tomato mice, or by AAV6-Sox9p-shVEGFa, please refer to previous publications^13,15,16. GCPs, genome copy particles.