Skip to main content
. Author manuscript; available in PMC: 2016 Feb 1.
Published in final edited form as: Nat Neurosci. 2015 Mar 2;18(4):521–530. doi: 10.1038/nn.3966

Figure 5. Accelerated cognitive impairment in GLUT1-deficient APPSw/0 mice.

Figure 5

(a-c) Quantification of exploratory preference measuring hippocampal-dependent novel object location memory (a), novel object recognition memory (b), nest construction score (c) and mean locomotor activity (d) in 1- and 6-month-old Slc2a1+/+, Slc2a1+/−, Slc2a1+/+APPSw/0 and Slc2a1+/−APPSw/0 mice. Mean ± SEM, n=9-15 mice per group; *p<0.05 or **p<0.01. (e) Representative high-magnification bright-field microscopy microscopy analysis of Golgi-Cox staining showing dendritic spine density in the CA1 hippocampal region of 6-month-old Slc2a1+/+, Slc2a1+/−, Slc2a1+/+APPSw/0 and Slc2a1+/−APPSw/0 mice. (f) Quantification of dendritic spine density in 6-month-old Slc2a1+/+, Slc2a1+/−, Slc2a1+/+APPSw/0 and Slc2a1+/−APPSw/0 mice. Mean ± SEM, n=3-5 mice per group; *p<0.05 or **p<0.01.