Table 3.
Hazard Ratios (HR) of Colorectal Cancer Associated with Laxative Use, by Sex
| Men
|
Women
|
||||||
|---|---|---|---|---|---|---|---|
| Case/Cohorta | HRb | (95% CI) | Case/Cohorta | HRb | (95% CI) | P for interaction | |
|
|
|
||||||
| Non-Fiber Laxative Use (10 year) | |||||||
| <1x/year | 230/30,156 | 1.00 | Ref | 183/30,047 | 1.00 | Ref | 0.52 |
| 1–4x/year | 19/2,103 | 1.10 | (0.60–2.01) | 49/4,021 | 1.84 | (1.16–2.93) | |
| ≥5x/year | 9/806 | 2.34 | (0.96–5.66) | 17/2,645 | 1.14 | (0.57–2.31) | |
| Ptrend | 0.13 | 0.18 | |||||
| Fiber Laxative Use (10 year) | |||||||
| Non-User | 248/31,178 | 1.00 | Ref | 238/32,935 | 1.00 | Ref | 0.48 |
| Low (<4 days/week or <4 yrs) | 17/2,356 | 1.19 | (0.69–2.05) | 27/3,891 | 1.14 | (0.70–1.86) | |
| High (4+ days/week for 4+ yrs) | 6/1,504 | 0.41 | (0.13–1.30) | 5/1,765 | 0.48 | (0.18–1.31) | |
| Ptrend | 0.33 | 0.39 | |||||
a
n: # after fter adjustment for all covariates (listed below)
b
Adjusted for: age, sex, race/ethnicity,education, smoking, BMI, physical activity, family history of CRC, colonoscopy/sigmoidoscopy screening, history of polyp removal, aspirin use, NSAID use, hormone replacement therapy use (among women), caloric intake, fiber, fruit & vegetable intake, red/processed meat intake, alcohol consumption, calcium, non-fiber laxative use, fiber laxative use, bowel movement frequency and constipation