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. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: J Steroid Biochem Mol Biol. 2015 Aug 1;160:189–195. doi: 10.1016/j.jsbmb.2015.07.022

Figure 2. Effects of chronic and acute estrogen treatment on NOR and NOP.

Figure 2

A. Chronic estradiol treatment – Ovx rats received two days of S.C. injections with vehicle or 50 ug/kg of estradiol benzoate (EB), and NOR and NOP was tested separately 48 h after the last dose. Entries are ratios (new/old + new) of time spent exploring each object (NOR) or objects in each location (NOP) for vehicle- and EB-treated subjects. Dotted line at 0.5 indicates spending the same amount of time exploring new and old objects or locations. ** P < 0.01 *** P < 0.001 by Mann-Whitney U-tests. Redrawn from Jacome et al [11].

B. Acute Estradiol treatment – Ovx rats received vehicle or 5 ug/kg (NOR) or 20 ug/kg (NOP) of estradiol immediately after a Training Trial. 4 h later NOR and NOP were separately tested. Data presented as in A. ** P < 0.01. Redrawn from Inagaki et al [14].