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Ace2 does not play a role in acute hepatocellular injury. Ace2 KO mice and wt littermates were subjected to different models of acute liver injury: BDL for 5 days (A,B), single injection of CCl4 (C,D), and ischemia-reperfusion injury (E,F). No differences were observed between ace2 KO mice and wt littermates as evaluated by hematoxylin and eosin staining (A,C,E) and serum ALT levels (B,D,F). Data are presented as mean ± SEM; n.s. indicates not significant.
