Table 1.
Review of IgG4-related tubulointerstitial nephritis
| References | No. of cases | Age (median, yr) | Male:Femlae | Extrarenal lesion | Serum IgG (median, mg/dL) | Serum lgG4 (median, mg/dL) | SCr at biopsy (mean) | Elevated Cr (>1.2 mg/dL) | ANA (+) | RF (+) | Proteinuria (> 1 g/day) | Hematuria | Renal biopsy finding |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Saeki et al. [7] | 23 | 40-83 (64) | 20:3 | Sa (19), LN (10), Pa (9), La (7), Lu (6), Li (1), Pr (1) | 2,721-8,841 (4,387) | 305-4,630 (1,330) | 0.67-6.87 (1.98) | 13/23 | 16/23 | 7/18 | 2/23 | 8/23 | TIN (23/23), MGN (1/23), mild MPGN (3/23), focal segmental EC (1/23) |
| Raissian et al. [8] | 35 | 20-84 (67) | 30:5 | Sa (6), LN (8), Pa (15), La (1), Lu (8), Li (7), RP(3) | - | - | 0.9-9.0 (3.57) | 27/35 | 10/32 | - | 8/27 | 6/27 | TIN (35/35), MGN (2/35), many eosinophils (4/35) |
| Kawano et al. [28] | 20 | 55-83 (70) | 18:2 | Jo (1), La (2), Li (1), LN (5), Lu (6), Ne (1), Pa (7), Pr (2), RP (1), Sa (12) | 1,679-5,380 (3,596) | 408-1,860 (828) | 0.59-7.26 (1.36) | 12/20 | - | - | 2/15 | - | TIN (20/20), MPGN (1), IgAN (1), EC (2), HSPN (2), MGN (3) |
| Yamaguchi et al. [13] | 16 | 45-78 (62) | 12:4 | Pa (8), Sa (7), RP (1), Lu (1), Li (1) | 1,569-6,328 (3,604) | 142-2,120 (958) | 0.84-6.17 (1.6) | 12/16 | - | - | 3/11 | - | TIN (16/16), MGN (2) |
SCr, serum creatinine; Cr, creatinine; ANA, antinuclear antibodies; RF, rheumatoid factor; Sa, salivary gland; LN, lymph node; Pa, pancreas; La, lacrimal gland; Lu, lung; Li, liver; Pr, prostate; TIN, tubulointerstitial nephritis; MGN, membranous nephropathy; MPGN, membranoproliferative glomerulonephritis; EC, endocapillary hypercellularity; RP, retroperitoneum; Jo, joint; Ne, nerve; IgAN, IgA nephropathy; HSPN, Henoch-Schönlein purpura nephritis.