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Skin inflammation in filaggrin-deficient mice. A, Fold change in Ifng, Il4, and Il17 mRNA expression (n = 6-8 per group) in skin. Data are representative of 3 experiments. B-D, Cytokine quantification in nonlesional skin expressed as nanograms of cytokine per milligram of protein. Data are from 25 to 35 mice per strain. Statistical significance was determined with the Student t test. *P < .05 and **P < .01. NS, Nonsignificant.
