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. Author manuscript; available in PMC: 2017 Jan 1.
Published in final edited form as: Biomaterials. 2015 Oct 30;77:130–138. doi: 10.1016/j.biomaterials.2015.10.074

Figure 2.

Figure 2

Surface plasmon resonance (SPR)-based studies of HA and s-HAs binding to VEGF165a and VEGF165b. (A) Schematic of surface modification of gold SPR chip with VEGF and SPR-based binding studies. (B-D) The binding response of the sodium salt of HA or s-HAs to VEGF165a (black bar) or VEGF165b (empty bar) as a function of molecular weight (17 kDa, 150 kDa, 1,000 kDa) at 200 msec after injection. (E-G) The binding response of pyridine and tetrabutylammonium (TBA) salts of HA or s-HAs with VEGF165a (black bar) or VEGF165b (empty bar) as a function of HA molecular weight at 200 msec after injection. The data in Fig. 2B-G are mean values of triplicate SPR responses obtained at 200 sec after the injection of sample solutions.