Table 2.

Univariate and multivariate analyses of the FA values in the different ROIs according to socio-demographic, clinical characteristics and CR

		ANOVA						MANOVA
		Anterior Insula		Cingulate gyrus		Uncinate gyrus		Left		Right
	N	Left	Right	Left	Right	Left	Right	Wilks’ Lambda /F	p-value	Wilks’ Lambda/F	p-value
		$\overline{x}\left(sd\right)$	$\overline{x}\left(sd\right)$	$\overline{x}\left(sd\right)$	$\overline{x}\left(sd\right)$	$\overline{x}\left(sd\right)$	$\overline{x}\left(sd\right)$
Total		0.64 (0.05)	0.60 (0.06)	0.75 (0.04)	0.73 (0.05)	0.66 (0.03)	0.68 (0.04)
Sex					** (0.0322)			0.988/0.19	0.9036	0.873/2.32	0.0870
- Male	5	0.63 (0.05)	0.60 (0.05)	0.75 (0.05)	0.69 (0.04)	0.66 (0.04)	0.66 (0.06)
- Female	47	0.64 (0.05)	0.60 (0.06)	0.75 (0.04)	0.74 (0.05)	0.67 (0.04)	0.69 (0.03)
Assessment at baseline and 3 months				*(0.1793)	*(0.0987)			0.924/0.63	0.7068	0.908/0.77	0.5929
- Controls	15	0.65 (0.05)	0.61 (0.05)	0.76 (0.04)	0.75 (0.04)	0.67 (0.03)	0.69 (0.02)
- Episodics	19	0.64 (0.04)	0.59 (0.07)	0.74 (0.04)	0.74 (0.05)	0.66 (0.03)	0.68 (0.03)
- Chronic migraneurs	18	0.63 (0.05)	0.59 (0.06)	0.75 (0.05)	0.71 (0.05)	0.66 (0.04)	0.68 (0.05)
Assessment at 6 months		*(0.0645)	**(0.0457)	**(0.0274)	**(0.0170)	*(0.0645)	**(0.0274)	0.666/3.34	0.0400	0.640/3.75	0.0276
- Controls	15	0.65 (0.05)	0.61 (0.05)	0.76 (0.04)	0.75 (0.04)	0.67 (0.03)	0.69 (0.02)
- LTCM	9	0.61 (0.05)	0.57 (0.05)	0.72 (0.04)	0.70 (0.04)	0.64 (0.04)	0.65 (0.05)
Preventive therapy		** (0.0115)	* (0.1261)	* (0.1358)	** (0.0470)	** (0.0420)	* (0.1192)	0.851/2.79	0.0502	0.915/1.49	0.2288
- No	33	0.65 (0.04)	0.61 (0.06)	0.75 (0.04)	0.74 (0.04)	0.67 (0.03)	0.69 (0.03)
- Yes	19	0.62 (0.05)	0.59 (0.05)	0.74 (0.04)	0.72 (0.05)	0.65 (0.04)	0.67 (0.04)
Cognitive reserve			** (0.0097)	** (0.0402)	** (0.0202)		* (0.1497)	0.731/1.71	0.0940	0.673/2.20	0.0268
- ≤11	13	0.63 (0.06)	0.59 (0.04)	0.76 (0.04)	0.72 (0.05)	0.66 (0.03)	0.67 (0.04)
- 12–15	13	0.63 (0.05)	0.56 (0.07)	0.72 (0.05)	0.71 (0.04)	0.66 (0.04)	0.67 (0.04)
- 16–18	15	0.65 (0.04)	0.63 (0.03)	0.75 (0.03)	0.76 (0.04)	0.67 (0.03)	0.70 (0.03)
- >18	11	0.65 (0.05)	0.62 (0.06)	0.77 (0.02)	0.74 (0.05)	0.68 (0.04)	0.69 (0.03)

$\overline{x}\left(sd\right)$: Mean (standard deviation). N Frequency. ** Statistical significance p < 0.05. * 0.05 < p-value ≤ 0.20. LTCM Long-Term Chronic Migraneurs