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. 2016 Feb 2;7:55. doi: 10.3389/fmicb.2016.00055

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Copyright © 2016 Huang, Liang, Guo, Shang, Ge, Kashif and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Genomic organization of the ICESa2603 family. HS-1, HS-2, and HS-3 were the hotspots of ICESa2603 family, which were presented in all ICEs. I-1, I-2, I-3, and I-4 could also receive additional genes in part of the ICEs. Genes are shown in different colors: black, ICEs core genes; navy, int and xis; azure, nisin operon genes; red, T4SS genes; green, antibiotic and heavy metal resistance genes; purple, other cargo genes. (A); ICESa2603 family ICEs. (B); ICESa2603 family-like ICEs.