Table 2.
Comparison of macrolide resistance genotypes of Streptococcus pneumoniae isolates in three periods by age
| Macrolide resistance genotype | Noninvasive S. pneumoniae isolates, n (%), for: |
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|---|---|---|---|---|---|---|---|---|---|
| Pre-PCV7 routine immunization period (previous study in 2011) |
PCV7 routine immunization period (April–October 2013) |
PCV13 routine immunization period (November 2013–November 2014 |
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| All ages (n = 1061) | <16 years (n = 998) | ≥16 years (n = 63) | All ages (n = 1097) | <16 years (n = 975) | ≥16 years (n = 122) | All ages (n = 960) | <16 years (n = 873) | ≥16 years (n = 87) | |
| erm(B)+ | 704 (66.4) | 671 (67.2) | 33 (52.4) | 807 (73.6) | 711 (73.0) | 96 (78.7) | 721 (75.1) | 653 (74.8) | 68 (78.2) |
| mef (A/E)+ | 424 (40.0) | 396 (39.7) | 28 (44.4) | 307 (28.0) | 278 (28.5) | 29 (23.8) | 303 (31.6) | 282 (32.3) | 21 (24.1) |
| erm(B)+ and mef(A/E)+ | 113 (10.7) | 109 (10.9) | 4 (6.3) | 79 (7.2) | 70 (7.2) | 9 (7.4) | 108 (11.3) | 100 (11.5) | 8 (9.2) |
| erm(B)+ and mef(A/E)− | 591 (55.8) | 562 (56.3) | 29 (46.0) | 728 (66.4) | 641 (65.7) | 87 (71.3) | 613 (63.9) | 553 (63.3) | 60 (69.0) |
| erm(B)− and mef(A/E)+ | 311 (29.3) | 287 (28.8) | 24 (38.1) | 228 (20.8) | 207 (21.3) | 20 (16.4) | 195 (20.3) | 182 (20.8) | 13 (14.9) |
| erm(B)− and mef(A/E)− | 46 (4.3) | 40 (4.0) | 6 (9.5) | 62 (5.7) | 56 (5.7) | 6 (4.9) | 44 (4.6) | 38 (4.4) | 6 (6.9) |
PCV, pneumococcal conjugate vaccine.