Table 1.

Main extrahepatic manifestations in patients with hepatitis C virus infection.

Immune-related extrahepatic manifestations

Mixed cryoglobulinemia

Cryoglobulinemic vasculitis

B-cell NHL

Sicca syndrome

Arthralgia/myalgia

Autoantibody production (i.e. cryoglobulins, rheumatoid factor, and antinuclear, anticardiolipin, antithyroid and anti-smooth muscle antibodies)

Polyarteritis nodosa

Monoclonal gammopathies

Immune thrombocytopenia

Inflammatory-related extrahepatic manifestations

Type 2 diabetes mellitus type 2

Insulin resistance

Glomerulonephritis

Renal insufficiency

Fatigue

Cognitive impairment

Depression

Impaired quality of life

Polyarthritis/fibromyalgia

Cardiovascular disorders (i.e. stroke, ischemic heart disease)

NHL, non-Hodgkin’s lymphoma.